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Infectious Disease: Parasitic Diseases
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Traveling 2,700 miles to save Jesus’s arm
When you talk to Jesus Barradas, he is like any other 16-year-old boy, into music, soccer, video games and television.
But when the Veracruz, Mexico native raises his left arm, you can see that something isn’t right. The forearm is much larger than his right. His left hand is swollen, the fingers curled into a near-permanent claw shape, and he holds it gingerly, almost cradling it protectively.
Jesus was born with a vascular malformation in his arm called FAVA (fibroadipose vascular anomaly), which keeps blood from draining properly out of the tissues of his forearm. It’s both physically and emotionally painful...
Source: Thrive, Children's Hospital Boston - September 9, 2014 Category: Pediatrics Authors: Tom Ulrich Tags: All posts arm FAVA fibroadipose vascular anomaly Vascular Anomalies Center (VAC) vascular malformation Source Type: news
Proteomic mapping of the lung vascular endothelial cell surface in Schistosoma bovis-infected hamsters.
The objective of this work was to analyse the changes induced by Schistosoma bovis schistosomula in the proteome expressed by infected hamsters, over 10 and 20days, on the endothelial surface of their pulmonary vasculature. To accomplish this, we subjected the lungs of non-infected and S. bovis-infected hamsters to vascular perfusion with a biotin ester reactive. Analysis by liquid chromatography and tandem mass spectrometry analysis (LC-MS/MS) of endothelial surface proteins resulted in the identification of a total of 459 non-redundant proteins in the lung vasculature of infected and non-infected hamsters. Here we report...
Source: Journal of Proteomics - April 23, 2014 Category: Biochemistry Authors: de la Torre-Escudero E, Pérez-Sánchez R, Manzano-Román R, Oleaga A Tags: J Proteomics Source Type: research
A Developmental Framework for Graft Formation and Vascular Reconnection in Arabidopsis thaliana.
Abstract
Plant grafting is a biologically important phenomenon involving the physical joining of two plants to generate a chimeric organism. It is widely practiced in horticulture and used in science to study the long-distance movement of molecules. Despite its widespread use, the mechanism of graft formation and vascular reconnection is not well understood. Here, we study the dynamics and mechanisms of vascular regeneration in Arabidopsis thaliana during graft formation when the vascular strands are severed and reconnected. We demonstrate a temporal separation between tissue attachment, phloem connection, root gr...
Source: Current Biology - April 15, 2015 Category: Biology Authors: Melnyk CW, Schuster C, Leyser O, Meyerowitz EM Tags: Curr Biol Source Type: research
Insights on the Gut-Mesentery-Lung Axis in Pulmonary Arterial Hypertension: A Poorly Investigated Crossroad
Arterioscler Thromb Vasc Biol. 2022 Mar 17:ATVBAHA121316236. doi: 10.1161/ATVBAHA.121.316236. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the hyperproliferation of vascular cells, including smooth muscle and endothelial cells. Hyperproliferative cells eventually obstruct the lung vasculature, leading to irreversible lesions that collectively drive pulmonary pressure to life-threatening levels. Although the primary cause of PAH is not fully understood, several studies have indicated it results from chronic pulmonary inflammation, such as observed in resp...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 17, 2022 Category: Cardiology Authors: Suellen Darc Oliveira Source Type: research
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
Abstract
Leishmania and Trypanosoma parasites are responsible for the challenging neglected tropical diseases leishmaniases, Chagas disease and Human African Trypanosomiasis, which account for up to 40,000 deaths annually mainly in developing countries. Current chemotherapy relies on drugs with major limits of efficacy and safety, prompting the urgent need of exploring innovative approaches to improve the drug discovery pipeline. The unique trypanothione-based redox pathway, which is absent in the human host, is vital for all trypanosomatids and offers valuable opportunities to guide the rational development of sp...
Source: ChemMedChem - August 16, 2020 Category: Chemistry Authors: Saccoliti F, Di Santo R, Costi R Tags: ChemMedChem Source Type: research
Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension
Schistosomiasis is a prevalent cause of pulmonary arterial hypertension (PAH), currently classified as group 1 pulmonary hypertension (PH) [1]. In comparison to other aetiologies of PAH, such as idiopathic PAH, schistosomiasis-associated PAH (Sch-PAH) has not been extensively studied. Potential mechanisms of PAH development in schistosomiasis include systemic and localised lung inflammation, involvement of other organs, such as the liver and spleen, and direct blockage of precapillary vessels from parasite egg embolisation. Currently, the diagnosis of Sch-PAH relies on haemodynamic assessment using right heart catheterisat...
Source: European Respiratory Journal - May 6, 2021 Category: Respiratory Medicine Authors: Rahaghi, F. N., Hilton, J. F., Correa, R. A., Loureiro, C., Ota-Arakaki, J. S., Verrastro, C. G. Y., Lee, M. H., Mickael, C., Nardelli, P., Systrom, D. A., Waxman, A. B., Washko, G. R., San Jose Estepar, R., Graham, B. B., Oliveira, R. K. F. Tags: Original Articles: Research letters Source Type: research
Parasitological and molecular search for leishmania natural infection in phlebotomine sand flies in peri-urban sites of an argentinean area endemic for tegumentary leishmaniasis
Acta Trop. 2021 Jul 21:106064. doi: 10.1016/j.actatropica.2021.106064. Online ahead of print.ABSTRACTLeishmaniases are neglected tropical diseases caused by Leishmania spp. parasites transmitted by the bite of phlebotomine sand flies. In Argentina, the most endemic area of American Tegumentary leishmaniasis (ATL) has been Orán department, Province of Salta, where Leishmania (Viannia) braziliensis prevails and Nyssomyia neivai is considered as its vector, although there is no accurate and sufficient information in this regard. The aim of this work was to search for natural infection by Leishmania spp. in sand flies from pe...
Source: Acta Tropica - July 24, 2021 Category: Infectious Diseases Authors: Mar ía Cristina Almazán Griselda Noem í Copa Jos é Fernando Gil In és López Quiroga Melisa Evangelina D íaz Fernández Alejandro Uncos Carlos Lorenzo Hoyos Julio Rub én Nasser Paola Andrea Barroso Jorge Diego Marco Source Type: research
Parasitological and molecular search for leishmania natural infection in phlebotomine sand flies in peri-urban sites of an argentinean area endemic for tegumentary leishmaniasis
Acta Trop. 2021 Jul 21:106064. doi: 10.1016/j.actatropica.2021.106064. Online ahead of print.ABSTRACTLeishmaniases are neglected tropical diseases caused by Leishmania spp. parasites transmitted by the bite of phlebotomine sand flies. In Argentina, the most endemic area of American Tegumentary leishmaniasis (ATL) has been Orán department, Province of Salta, where Leishmania (Viannia) braziliensis prevails and Nyssomyia neivai is considered as its vector, although there is no accurate and sufficient information in this regard. The aim of this work was to search for natural infection by Leishmania spp. in sand flies from pe...
Source: Acta Tropica - July 24, 2021 Category: Infectious Diseases Authors: Mar ía Cristina Almazán Griselda Noem í Copa Jos é Fernando Gil In és López Quiroga Melisa Evangelina D íaz Fernández Alejandro Uncos Carlos Lorenzo Hoyos Julio Rub én Nasser Paola Andrea Barroso Jorge Diego Marco Source Type: research
< em > Rickettsia conorii < /em > : Unusual case of acute aortic thrombosis
CONCLUSION: The patient was successfully operated using open aortic surgery and subsequent treatment with doxycycline. To our knowledge, this is the first report of aortic thrombosis associated with infection by this parasite, extending the clinical spectrum of the disease.PMID:36052837 | DOI:10.1177/17085381221124986
Source: Vascular - September 2, 2022 Category: Surgery Authors: Iria Fern ández Álvarez Javier Fern ández Lorenzo Jose Manuel Encisa de S á Source Type: research
Automatic diagnosis of malaria based on complete circle–ellipse fitting search algorithm
This study presents an automatic method for malaria diagnosis from thin blood smears. According to this fact that malaria life cycle is started by forming a ring around the parasite nucleus, the proposed approach is mainly based on curve fitting to detect parasite ring in the blood smear. The method is composed of six main phases: stain object extraction step, which extracts candidate objects that may be infected by malaria parasites. This phase includes stained pixel extraction step based on intensity and colour, and stained object segmentation by defining stained circle matching. Second step is preprocessing phase which ...
Source: Journal of Microscopy - September 19, 2013 Category: Laboratory Medicine Authors: M. SHEIKHHOSSEINI, H. RABBANI, M. ZEKRI, A. TALEBI Tags: Original Article Source Type: research
Vascular Diseases in Birds of Prey
Abstract: In birds of prey, vascular disease can be caused by a number of infectious or noninfectious agents and is in all likelihood underdiagnosed. This review attempts to provide a discussion of the available literature regarding vascular diseases in raptors by describing a number of conditions or etiological agents (e.g., atherosclerosis, aneurysms, bacterial and septicemic conditions, thromboembolic disease, and viral, fungal, parasitic, and miscellaneous diseases) and the vascular pathology that may occur with each.
Source: Journal of Exotic Pet Medicine - October 1, 2013 Category: Veterinary Research Authors: Michael P. Jones Tags: Topics in Medicine and Surgery Source Type: research
